Abstract

The histone H3 lysine 27 methyltransferase EZH2 takes part in heterochromatin formation and gene transcription regulation.EZH2 is frequently over-expressed in a wide variety of cancerous tissue types,which reveals it to be oncogenic.However,in myeloid malignancies,EZH2 could act as a tumor suppressor.This paper mainly reviews the structure and function of EZH2 and its effect on hematologic neoplasms.Taking EZH2 as target will provide systematic understanding for the treatment of hematologic neoplasms. Key words: Hematologic neoplasms; EZH2; Histone methyltransferase; Epigenetic

Talk to us

Join us for a 30 min session where you can share your feedback and ask us any queries you have

Schedule a call

Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.