Abstract
Epstein-Barr virus(EBV) infection is characterized as chronic or recurrent infectious mononucleosis (IM)-like symptoms, such as fever, extensive lymphadenopathy, hepatosplenomegaly and persistent hepatitis. Additionally, the expression of EBV specific antibody spectrum and a significant incrcase of EBV DNA copies are often demonstrated in peripheral blood of patients with chronic active Epstein-Barr virus infection (CAEBV). CAEBV is a rare fatal disease with poor prognosis and high mortality. The pathogenesis of CAEBV is unknown and there is no standarlized treatment. In order to improve understanding of CAEBV in the clinical work, this article summarizes the pathogenesis, clinical features, diagnose and therapies of CAEBV. Key words: Epstein-Barr virus infections; Diagnosis; Therapeutics
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