Abstract
Aplastic anemia (AA) is considered as an immune-mediated bone marrow failure syndrome, characterized by peripheral pancytopenia and destruction of hematopoietic stem/progenitor cells. Acquired aplastic anemia (aAA) is more common in clinic. Abnormal immunity is one of the major factors mediating the pathogenesis of aAA. This review discusses the current understanding of the immunobiology in aAA, so as to clarify the immune mechanism of this disease, and to provide a theoretical basis for the clinical treatment of aAA. Key words: Anemia, aplastic; Immunity; Immunosuppressive agent; Children; Acquired aplastic anemia
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