Abstract
短QT综合征是以QT间期缩短、心脏性猝死高风险为特征的遗传性心脏离子通道病。它属于常染色体显性遗传，发病罕见，与编码钾通道和钙通道的基因突变有关，基因突变导致的I(Kr)、I(Ks)、I(K1)增大和I(Ca，L)功能丢失，使净外向电流增加或内向电流减少，复极加速，动作电位时程缩短和复极离散度增加，最终触发室性心动过速/心室颤动（VT/VF）。植入式心脏复律除颤器是唯一有效的防治心脏性猝死的手段，奎尼丁和索他洛尔通过延长有效不应期和QT间期，可有效预防VT/VF。.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
