Abstract
Fibroblast growth factor receptor 1 (FGFR1) is a member of receptor tyrosine kinase family.Recently,FGFR1 amplification has been found in 20％ of patients with squamous cell carcinoma of the lung and rarely in lung adenocarcinoma,and experiments reveal that it has direct association with the smoking dosage significantly.In vivo studies have demonstrated inhibition of the FGFR1 pathway with FGFR1 inhibitors lead to significant shrinkage of tumor,suggesting that FGFR1 inhibitors might be an effective therapeutic option in squamous cell carcinoma of lung with FGFR1 amplification.And FGFR1 tyrosine kinase inhibitors are currently in early phase clinical testing.FGFR1 represents a potential therapeutic target in squamous cell carcinoma of lung.This review focuses on biological characteristics of FGFs/FGFRs signal pathways,FGFRs in tumor,the expression of FGFR1 amplification in lung cancer and progress of targeted drugs as well as relationship of it with clinic. Key words: Lung cancer; Fibroblast growth factor receptor 1 amplification; Smoking; Clinical parameter
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