Abstract
An epidemiologic study of the parents and siblings of 216 children with Down's syndrome and of 216 control children matched on the basis of maternal age at the time of the child's birth demonstrated no differences in the frequencies of abortions, stillbirths, or congenital abnormalities, nor did the siblings of the children with Down's syndrome have a higher frequency of deaths from acquired causes than did the siblings of the controls. Mothers in the two groups were similar in fertility and there were no differences in their menstrual histories. A significantly higher frequency of multiple marriages prior to the birth of the index child was observed in the mothers of the affected children. Some possible interpretations of these observations are discussed.
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