Abstract
The purpose of this study was to prospectively evaluate the reproducibility of the proton density fat-fraction (PDFF) of the liver using the IDEAL algorithm, a quantitative confounder-corrected chemical-shift-encoded MRI method. Data were obtained from 15 volunteers on four different days. The first and the third examinations were conducted on scanner one with one-week intervals, while the second and the fourth tests were performed on scanner two with same time interval. For each test, two MR scans were performed, one before and one after a meal. Regions-of-interest measurements were manually calculated to estimate the PDFF in the right and left lobes on the PDFF images. Reproducibility was measured using the intra-class correlation coefficient (ICC). The ICCs of the PDFF in the right and left lobes were 0.935 and 0.878, respectively. The intra-scanner ICCs of the right lobe before and after a meal or at a one-week interval were 0.924 and 0.953, respectively. The inter-scanner ICCs of PDFF the next day and at a one-week interval were 0.920 and 0.864, respectively. The PDFF of liver derived from IDEAL demonstrated high intra- and inter-scanner measurement reproducibility. The PDFF of the right lobe before a meal was more reproducible than after-meal measurements.
Highlights
Hepatic steatosis is characterized by the excessive accumulation of lipids within hepatocytes, which is an essential feature of diffuse liver diseases, such as nonalcoholic fatty liver disease, alcoholic liver disease, viral hepatitis, genetic lipodystrophies, cystic fibrosis liver disease, and hepatotoxicity due to numerous therapeutic drugs
Vivo, which aimed to evaluate the reproducibility of different scanners at different time scales, in different lobes of the liver, or under different levels of stomach emptiness on two respective 3.0 T Magnetic resonance (MR) scanners with the same algorithm, IDEAL IQ
The intra-scanner intra-class correlation coefficient (ICC) of the right liver lobe before meals at one-week intervals was 0.953
Summary
Hepatic steatosis is characterized by the excessive accumulation of lipids within hepatocytes, which is an essential feature of diffuse liver diseases, such as nonalcoholic fatty liver disease, alcoholic liver disease, viral hepatitis, genetic lipodystrophies, cystic fibrosis liver disease, and hepatotoxicity due to numerous therapeutic drugs. Advanced MR applications measure the proton density fat-fraction (PDFF), defined as the proportion of the mobile proton density in liver tissue attributable to fat, which is a fundamental tissue property and represents the direct measurement of liver fat content. These advanced MR approaches present accurate fat quantification with a commercially available cost. The reproducibility of the fat-fraction technique is essential to ensure that the quantified data can be pooled from different time scales or from different scanners. The current prospective pilot study was conducted to assess the reproducibility of PDFF as a biomarker for liver fat content in www.nature.com/scientificreports/. Vivo, which aimed to evaluate the reproducibility of different scanners at different time scales, in different lobes of the liver, or under different levels of stomach emptiness on two respective 3.0 T MR scanners with the same algorithm, IDEAL IQ (software product, GE Healthcare)
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
