Abstract
Results A higher mean cell count was obtained using pooled lavage (means of 342 and 304 vs. 243 and 246, p=0000.4). The mean eosinophil percentage was comparable for both methods (for >100 cell count samples, 7% and 4% for single compared to 5% and 5% for pooled lavage, p=0.2). Single sample lavage produced a higher intraclass correlation (ICC) for eosinophil percentage (0.695 vs. 0.583). A cutoff of 100 total cells gave the most reproducible eosinophil % with ICC of >0.8. The ICC was 0.87 for single sample lavage and 0.81 for pooled lavage with >100 and 0.671 for SSL and 0.535 for MSL with >20 cells. Neutrophil (p=0.2), lymphocyte (p=0.2), monocyte (p=0.3), or basophil (p=0.3) percentages were not significantly different.
Highlights
Nasal lavage is used to collect cells and inflammatory mediators from the nasal cavity
To compare the reproducibility of a single lavage versus three pooled lavages
The mean eosinophil percentage was comparable for both methods
Summary
Nasal lavage is used to collect cells and inflammatory mediators from the nasal cavity. Reproducibility of cell counts in nasal lavage: a comparison of pooled versus non-pooled nasal lavage samples Dominik A Nowak1*, Penelope Ferrie2, Paul K Keith2 From Canadian Society of Allergy and Clinical Immunology Annual Scientific Meeting 2010 Victoria, Canada. Background Nasal lavage is used to collect cells and inflammatory mediators from the nasal cavity.
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