Abstract
A previous study observed that reported childhood abuse moderated psychotic and emotional reactivity to stress among patients with non-affective psychotic disorder. However, that study used a type of analysis unsuited for skewed data. This study aimed (1) to replicate the study and (2) to examine whether we would obtain similar results using a statistical approach better suited to skewed data. Fifty-nine patients with non-affective psychotic disorder were examined for up to 6 days using an intensive diary method to assess levels of negative affect, psychosis, and daily-life stress. A mixed-linear regression largely replicated earlier findings, but a two-component analysis failed to replicate the moderating effect of reported childhood abuse. These results illustrate the importance of exploring different statistical approaches to skewed data. They may also indicate that stress sensitization does not offer a complete account for the effect of reported childhood abuse on psychotic symptom severity.
Highlights
A growing body of evidence indicates that childhood abuse plays a role in the etiology of non-affective psychotic disorder (NAPD) [1,2,3,4]
Results showed that reported childhood abuse (RCA) significantly moderated the relationship between activity stress and negative affect (b = 0.03, 95% confidence intervals (CIs) [0.01, 0.06], p = 0.02), TABLE 1 | Demographic and clinical characteristics of 59 patients with non-affective psychotic disorder who completed electronic diaries and reported on stress reactivity
Main effects of stress on negative affect and psychotic experiences were not replicated in the mixed-effects logistic regression, but were replicated in the mixed-effects gamma-regression
Summary
A growing body of evidence indicates that childhood abuse plays a role in the etiology of non-affective psychotic disorder (NAPD) [1,2,3,4]. It has been suggested that an increased reactivity to stressful situations accounts for this [5,6,7]. ESM is especially useful for examining dynamic processes in daily life, because it involves prompting participants to report on their experiences multiple times per day for an extended period of time. In this way, ESM constitutes an ecologically valid approach for the measurement of pathological experiences and stressors in daily life
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