Abstract
The diagnosis of melanocytic lesions can be challenging and immunohistochemical study is a valuable tool for dermatopathologists. We report two cases initially simulating melanoma in situ, reviewing the histopathological and immunohistochemical findings and the cases published in the literature with similar findings/results. We emphasize the importance of clinicopathological correlation in the evaluation of lesions with interface changes and in the pseudomelanocytic nests, which may simulate melanoma in situ. We also highlight the importance of using a immunohistochemistry panel in addition to Melan-A, in the study of these lesions.
Highlights
Case reportRecent studies have emphasized the difficulties in distinguishing between epithelial pseudo-nests seen in interface dermatitis and true melanocytic nests[1,2,3,4,5,6]
We report two cases initially simulating melanoma in situ, reviewing the histopathological and immunohistochemical findings and the cases published in the literature with similar findings/results
Melan-A/MART-1 is one of the most important melanocytic markers[1] labeling premelanosomes, which act as target for cytotoxic T lymphocytes, and is expressed by normal melanocytes and most melanomas[4, 5, 9]
Summary
Case reportRecent studies have emphasized the difficulties in distinguishing between epithelial pseudo-nests seen in interface dermatitis and true melanocytic nests[1,2,3,4,5,6]. Immunohistochemical staining may not be helpful, since the most widely used marker for melanocytic lesions, the Melan-A can label injured keratinocytes[4, 6].
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