Abstract
We appreciate the comments from Dr. Wang-Dong Xu et al. It has been confirmed that hypoxia-inducible factor 1α (HIF-1α) regulates the expression of Notch-1 in Rheumatoid arthritis (RA) synovial fibroblast cell (RASFC) under hypoxia(1). Furthermore, our study shows that HIF-1α directly regulates the expression of Notch-1 and Notch-3 in the hypoxic microenvironment(2). However, for cells to adapt to the hypoxia microenvironment, HIF-1α and Notch signal transduction regulate each other.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
