Abstract
Ocular surface reconstruction in severe cases of limbal stem cell deficiency (LSCD) continues to be one of the most challenging fields in ophthalmology. 1 Santos M.S. Gomes J.A. Hofling-Lima A.L. et al. Survival analysis of conjunctival limbal grafts and amniotic membrane transplantation in eyes with total stem cell deficiency. Am J Ophthalmol. 2005; 140: 223-230 Abstract Full Text Full Text PDF PubMed Scopus (132) Google Scholar , 2 Gomes J.A. Santos M.S. Ventura A.S. et al. Amniotic membrane with living related corneal limbal/conjunctival allograft for ocular surface reconstruction in Stevens Johnson syndrome. Arch Ophthalmol. 2003; 121: 1369-1374 Crossref PubMed Scopus (75) Google Scholar , 3 Gomes J.A. dos Santos M.S. Cunha M.C. Mascaro V.L. Barros J.N. de Sousa L.B. Amniotic membrane transplantation for partial and total limbal stem cell deficiency secondary to chemical burn. Ophthalmology. 2003; 110: 466-473 Abstract Full Text Full Text PDF PubMed Scopus (150) Google Scholar , 4 Solomon A. Ellies P. Anderson D.F. et al. Long-term outcome of keratolimbal allograft with or without penetrating keratoplasty for total limbal stem cell deficiency. Ophthalmology. 2002; 109: 1159-1166 Abstract Full Text Full Text PDF PubMed Scopus (266) Google Scholar A variety of features exert important influence in the prognosis of ocular surface reconstruction that includes the degree and laterality of LSCD, the extent of conjunctival involvement, the presence and cause of conjunctival inflammation, the tear film stability, and the external ocular adnexae functionality. Other factors that should be considered are the additional need of keratoplasty and immunosuppression, which also can affect the outcome after limbal stem-cell transplantation (LSCT). 1 Santos M.S. Gomes J.A. Hofling-Lima A.L. et al. Survival analysis of conjunctival limbal grafts and amniotic membrane transplantation in eyes with total stem cell deficiency. Am J Ophthalmol. 2005; 140: 223-230 Abstract Full Text Full Text PDF PubMed Scopus (132) Google Scholar , 4 Solomon A. Ellies P. Anderson D.F. et al. Long-term outcome of keratolimbal allograft with or without penetrating keratoplasty for total limbal stem cell deficiency. Ophthalmology. 2002; 109: 1159-1166 Abstract Full Text Full Text PDF PubMed Scopus (266) Google Scholar , 5 Schwartz G.S. Gomes J.A.P. Holland E.J. Preoperative staging of disease severity. in: Holland E.J. Mannis M.J. Ocular surface disease medical and surgical management. Springer-Verlag, New York2002: 158-167 Crossref Google Scholar Survival Analysis of Conjunctival Limbal Grafts and Amniotic Membrane Transplantation in Eyes With Total Limbal Stem Cell DeficiencyAmerican Journal of OphthalmologyVol. 141Issue 3PreviewWe read with great interest the article titled “Survival Analysis of Conjunctival Limbal Grafts and Amniotic Membrane Transplantation in Eyes With Total Limbal Stem Cell Deficiency” by Santos and associates1 The authors have provided an insight on the outcome of conjunctival limbal grafts. They also have studied the associated prognostic indicators that can assist in proper case selection for these grafts. We would like to make the following comments: Full-Text PDF
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