Abstract
The murine hepatitis viruses can readily establish persistent infections both in vivo and in vitro. In vivo, persistent infections, dependent upon the virus strain, and the age and genetic background of the host, can occur resulting in chronic hepatitis or chronic demyelination of the central nervous system (1). In vitro, these agents can establish persistent infections in both neural and non-neural cell lines (2,3,4) without the requirements for viral modifications or environmental manipulations such as the presence of viral antibody or interferon.KeywordsCell HybridPersistent InfectionSomatic Cell HybridMouse Hepatitis VirusHypoxanthine Phosphoribosyl TransferaseThese keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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