Abstract
Recent reports1,2,3 have established the principle that illnesses which on the basis of their similar clinical symptoms would be classified together as influenza can be caused by antigenically different viruses. The same principle must be taken into account when repeated attacks of influenza occur in an individual; that is, in a person who previously has had influenza a subsequent attack may be due to infection with a virus that is antigenically different from the one responsible for the earlier illness. That examples of that sort do occur will be shown by the results of the following experiments in which samples of serum obtained over a period of 4 to 5 years from persons who had had more than one attack of influenza were tested against two antigenically different viruses, the TM virus1,3 and the PR8 strain of the virus of epidemic influenza.4Patient A had 2, and Patient B had 3 attacks of influenza during the period of observation. The serums, which were 14 from each patient, included samples obtained a...
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