Abstract
Young male rats were given single x-ray doses of 100, 250, or 500 rads to the liver, then partially hepatectomized at time intervals up to 12 weeks to study persistence of mitotic inhibition and chromosome aberrations. Mitotic inhibition was greater as the dose increased and animals took longer to return to control levels. Initial levels of chromosome bridges appeared to vary linearly with dose and to persist at these levels for time intervals related to the dose (3 weeks after 500 rads). After this time, the level of bridges fell to approximately one-half that initially seen with no further change observed.
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