Abstract
Six dogs with congestive heart failure and ascites were studied for (a) renin, norepinephrine, water, sodium, potassium, calcium, and magnesium contents in cardiovascular tissues; (b) plasma renin activity and renin substrate; (c) renal renin activity, juxtaglomerular index, and glucose-6-phosphate dehydrogenase activity in macula densa cells, and α-glycero-6-phosphate dehydrogenase activity in macula densa cells and juxtaglomerular bodies. The most important findings were: (a) a significant decrease in renal renin activity and in the juxtaglomerular index coinciding with increased activities of glucose-6-phosphate and α-glycero-6-phosphate dehydrogenases in macula densa cells when compared with normal renal tissue; (b) a highly significant increase in norepinephrine content in branches of mesenteric veins combined with a decrease in norepinephrine content in most arteries studied; (c) a significant increase in the sodium content of most arteries studied, without any change in water content.
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