Abstract
The role of pharmacokinetics in determining the renal safety of non-steroidal anti-inflammatory drugs (NSAIDs) is not widely appreciated. Indeed, the impact of NSAIDs’ pharmacokinetics on efficacy and toxicity generally receives little attention and few studies examine this issue. However, pharmacokinetics could be an important determinant of NSAIDs’ renal safety. This paper discusses two emerging aspects of NSAIDs’ pharmacokinetics. Firstly, NSAIDs’ effects on renal function in patients susceptible to renal ischaemia and, secondly, the role of racemic inversion in determining ibuprofen’s duration of action.
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