Abstract
BackgroundVentricular arrhythmias play an important role in cardiovascular mortality especially in patients with impaired cardiac and autonomic function. The aim of this experimental study was to determine, if renal denervation (RDN) could decrease the inducibility of ventricular fibrillation (VF) in a healthy porcine biomodel.MethodsControlled electrophysiological study was performed in 6 biomodels 40 days after RDN (RDN group) and in 6 healthy animals (control group). The inducibility of VF was tested by programmed ventricular stimulation from the apex of right ventricle (8 basal stimuli coupled with up to 4 extrastimuli) always three times in each biomodel using peripheral extracorporeal oxygenation for hemodynamic support. Further, basal heart rate (HR), PQ and QT intervals and effective refractory period of ventricles (ERP) were measured. Technical success of RDN was evaluated by histological examination.ResultsAccording to histological findings, RDN procedure was successfully performed in all biomodels. Comparing the groups, basal HR was lower in RDN group: 79 (IQR 58; 88) vs. 93 (72; 95) beats per minute (p = 0.003); PQ interval was longer in RDN group: 145 (133; 153) vs. 115 (113; 120) ms (p < 0.0001) and QTc intervals were comparable: 402 (382; 422) ms in RDN vs. 386 (356; 437) ms in control group (p = 0.1). ERP was prolonged significantly in RDN group: 159 (150; 169) vs. 140 (133; 150) ms (p = 0.001), but VF inducibility was the same (18/18 vs. 18/18 attempts).ConclusionsRDN decreased the influence of sympathetic nerve system on the heart conduction system in healthy porcine biomodel. However, the electrophysiological study was not associated with a decrease of VF inducibility after RDN.
Highlights
Ventricular arrhythmias play an important role in cardiovascular mortality especially in patients with impaired cardiac and autonomic function
ECG changes at baseline Comparing renal denervation (RDN) and control group, basal heart rate (HR) was significantly lower in RDN group: 79 (58; 88) vs. 93 (72; 95) beats per minute, p = 0.003
PQ interval in RDN group was longer: 145 (133; 153) vs. 115 (113; 120) ms, p < 0.0001, and QTc intervals were comparable between RDN and control group: 402 (382; 422) vs. 386 (356; 437) ms, p = 0.1
Summary
Ventricular arrhythmias play an important role in cardiovascular mortality especially in patients with impaired cardiac and autonomic function. The aim of this experimental study was to determine, if renal denervation (RDN) could decrease the inducibility of ventricular fibrillation (VF) in a healthy porcine biomodel. A significant decrease of VT/VF was observed in two patients with dilated and hypertrophic cardiomyopathy and in a patient after acute myocardial infarction who all suffered from treatment-resistant electrical storms [19,20] The objective of this experimental study was to compare changes of electrophysiological parameters and inducibility of VF in a healthy porcine biomodel 40 days after RDN with a control group
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