Abstract
ObjectiveThis study aims to evaluate a possible influence of high‐ or low‐ salt intake during pregnancy on renal structure and renin‐angiotensin system in neonates in Wistar rats.MethodsPregnant rats were fed with normal, high or low‐salt diet (NR, HO and HR groups, respectively) from the first day of pregnancy until delivery. Kidneys of the newborns (6‐8/group) were collected in the first 24 hours of life. Total renalvolume (stereology) and kidney renin‐angiotensin system (indirect ELISA) were evaluated.Results (mean±SEM, p<0.05) HO NR HR Statistical analysis Dams weight (g) 351±23* 377±36 386±42 p&lt;0.05 vs HR Liter size (n) 14±0.82 14±0.65 14±0.53 NS Newborns Body weight (g) male 5.37±0.09* 6.47±0.07 6.45±0.08 p&lt;0.0001 vs NR and HR female 5.13±0.07* 6.05±0.09 5.99±0.08 p&lt;0.0001 vs NR and HR kidney weight (g) male 9.43±0.27 9.91±0.21 9.25±0.37 NS female 10.22±0.32 9.99±0.22 9.66±0.22 NS kidney volume (mm³) male 7.04±0.47 7.44±0.22 8.20±0.46 NS female 6.73±0.61 5.84±0.44 7.25±0.98 NS ANG II (%) male 75±6.33* 100 68.1±4.05* p&lt;0.05 vs NR ACE (%) male 95.4±13.5 100 82.5±6.68 NS ConclusionLow salt intake during pregnancy is associated with low birth weight. Renal angiotensin II content compared normal salt fed dams is lower in newborns from salt overloaded and restricted dams during pregnancy.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
