Abstract
Aims/Purpose: to analyse the relationship of lamina cribrosa (LC) thickness in patients with proliferative diabetic retinopathy (PDR) after vitrectomy with SiO tamponade with retrolaminar migration of intraocular silicone oil (SiO).Methods: This retrospective study included 35 patients with PDR after vitrectomy with SiO tamponade who underwent unenhanced head computed tomography for various clinical indications. All images were visually evaluated for subretinal and retrolaminar migration of SiO involving the anterior visual pathway (optic nerve, optic chiasm, and optic tract) and the ventricular system. LC thickness was measured with spectral domain optical coherent tomography (SD OCT) using LC_Thickness_programm.m and main_low_noise_filters_programm.m, based on the adaptive compensation algorithm for eliminating a high‐level noise in the deep layers of optic nerve and improving the visualization of the LC posterior border, as well as for processing B‐scan with a set of 3 digital filters: Butterworth Low‐pass Filter inverion image, Wavelet Low‐pass Filter Analysis Daubechies original and inversion image.Results: In our patients with PDR the average LC thickness was 697 ± 35 μm (589 to 768 μm), that was 1.9 times higher than in healthy people (p < 0.001). We detected subretinal and retrolaminar silicone oil migration in 10 of the 35 patients (28.57%), noting silicone oil at the optic nerve head (n = 2), retrolaminar optic nerve (n = 4), optic chiasm (n = 2), optic tract (n = 1) and in the lateral ventricles (n = 3). 3 patients had migration to 2 locations each (1 – in retrolaminar optic nerve and optic chiasm, 2 – in retrolaminar optic nerve and lateral ventricle). We compared the LC thickness of patients without and with subretinal and retrolaminar SiO migration. It was established that LC thickness of patients with subretinal and retrolaminar SiO migration was significantly less (589 to 658 μm) than in patients without SiO migration (673 to 768 μm). It should be noted that the number of cases positive for migration was small, limiting the statistical power and accuracy of the prevalence.Conclusions: A direct correlation between scleral LC thickness and retrolaminar migration of SiO in patients with PDR after vitrectomy with SiO tamponade was revealed.
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