Abstract
Background and objective: An ex vivo-produced oral mucosa equivalent (EVPOME) is composed of a stratified layer of human oral keratinocytes seeded onto a human acellular dermis, AlloDerm®. Our preliminary clinical study showed the EVPOME grafts had enhanced maturation of the underlying submucosal layer associated with rapid epithelial coverage. Results of our animal study suggested that grafting of the EVPOME onto an oral wound promotes re-epithlialization of oral mucosa in the healing process. The objective of the present study was to investigate the change in the basement membrane of EVPOME during the healing process after intraoral grafting in athymic mice.
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