Abstract
REM sleep behavior disorder (RBD) is a parasomnia characterized by loss of the normal paralysis of REM sleep, such that patient act out their dreams. It is strongly associated with neurodegenerative synucleinopathies, including PD, DLB and MSA. Of note, patients often present first with RBD (idiopathic/isolated RBD), and prospective studies suggest that >80% of iRBD patients will eventually develop a neurodegenerative disease, often 10–15 years post diagnosis. This presents a notable opportunity to intervene early in the process of neurodegeneration, before irreversible damage has occurred and (most notable for clinical trials) before symptomatic therapy confounds assessment of progression. In this talk, the diagnosis and treatment of RBD, and the potential of iRBD for the development of neuroprotective therapy against neurodegenerative synucleinopathy will be discussed.
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