Abstract
SummaryTwo triglyceride emulsions prepared for intravenous use in man have been examined for ability to release histamine from tissue mast cells in rat peritoneal cavity. The emulsions themselves had no direct action upon smooth muscle. Intraperitoneal injection of these materials caused rupture of the mast cells. The fluid recovered from the peritoneal cavity produced bronchiolar constriction in the pithed guinea pig and contraction of guinea pig ileum in vitro, indicating a significant histamine content. It is suggested that histamine release may play an important role in development of the occasional “anaphyloctoid” response following intravenous infusion of triglyceride emulsions in patients.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
