Release of gastric inhibitor from the intestine of dogs infused intravenously with sodium oleate.

Abstract

We found previously that intravenous infusion of sodium oleate induced inhibition of pentagastrin-stimulated gastric secretion in canine Heidenhain pouches. In the present study we attempted to verify the hypothesis that such intravenous infusion provoked Extract of intestinal mucosa release, from intestinal mucosa, of an enterogastrone-like inhibitor. Lyophilized extracts of canine intestinal secretion or mucosa were prepared using dogs infused for 6 h with saline or with sodium oleate. These extracts weren then assayed for their inhibitory action by intravenous infusion into Heidenhain pouches of dogs, stimulated with pentagastrin. When solvent or extracts prepared from intestinal juice or gut mucosa of dogs infused with saline were tested, no inhibition of gastric acid occurred. When extracts prepared from dogs infused with oleate were assayed, gastric acid secretion was inhibited. We concluded that intravenous infusion of fat results in the release of a gastric inhibitor of intestinal origin which behaves as an enterogastrone. This may be a most reasonable explanation of the action of intravenous sodium oleate on gastric secretion.