Abstract
Plantaricin 423, produced by Lactobacillus plantarum, and bacteriocin ST4SA produced by Enterococcus mundtii, were electrospun into nanofibers prepared from different combinations of poly(d,l-lactide) (PDLLA) and poly(ethylene oxide) (PEO) dissolved in N,N-dimethylformamide (DMF). Both peptides were released from the nanofibers with a high initial burst and retained 88% of their original antimicrobial activity at 37 °C. Nanofibers have the potential to serve as carrier matrix for bacteriocins and open a new field in developing controlled antimicrobial delivery systems for various applications.
Highlights
IntroductionBacteriocins (ribosomally synthesized antimicrobial peptides) and bacteriocin-like inhibitory substances (BLIS) are produced by several species of bacteria, including lactic acid bacteria that are generally recognized as safe [1,2,3]
Bacteriocins and bacteriocin-like inhibitory substances (BLIS) are produced by several species of bacteria, including lactic acid bacteria that are generally recognized as safe [1,2,3]
In this paper we studied the feasibility of electrospinning bacteriocins into nanofibers, as well as investigating the nanofibers as a delivery system
Summary
Bacteriocins (ribosomally synthesized antimicrobial peptides) and bacteriocin-like inhibitory substances (BLIS) are produced by several species of bacteria, including lactic acid bacteria that are generally recognized as safe [1,2,3]. (non-lanthionine-containing bacteriocins that do not undergo extensive post-translational modification) and the bacteriolysins [1]. Each of these groups can be further sub-divided. Lantibiotics can inhibit the germination of spores [8] Class IIa, or pediocin-like bacteriocins, mainly form pores in the membranes of sensitive cells [1]. By disrupting the PMF, cells cannot secrete antibiotics via transport systems located in their cell membranes. This could be an important answer to our search towards more effective ways of infection control. 60 to 70% are resistant to methicillin [9]
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