Abstract
Abstract The relaxation responses of aortic rings of rats fed either normal rat feed, 8% salt diet, 8% salt+2.5% Ca diet or 2.5% Ca diet for 6–8 weeks has been investigated. The mean arterial pressure of salt loaded rats (148.63±8.54 mmHg) was higher ( P P 2 ( P P −1 significantly ( P 4 in aortic rings from all the groups. The result of this study indicates that salt-loading caused significant increase in the blood pressure of the rats and also reduced the relaxation responses of the aortic rings to KCl, MgSO 4 and CaCl 2 which suggest altered Na + ,K + -ATPase activity and resistance of the vascular smooth muscle membrane to calcium-induced membrane stabilization. These defects were reversed by dietary calcium supplement.
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