Abstract
The status of the hypothalamo-pituitary-adrenal system (HPAS) and the group of regulatory neuropeptides synthesized in the zone of the medial small-cell hypothalamic subnucleus, the principal site of production of corticotropin-releasing factor, were studied in Wistar rats. HPAS was studied by radioimmunological and morpholiistochemical methods, the neuropeptidergic system by indirect immunofluorescence which helps measure the levels of neurotensin, bombesin, vasoactive intestinal peptide, leu- and met-enkeplialines, calcitonin-gene-related peptide, and cholecystokinin in the neurones and medial eminence of the hypothalamus. Development of diabetes mellitus in rats was found to be associated with an increase of HPAS activity and alteration of the peptidergic system presenting as an increase of the number of identified immunoreactive neurones and changed content of neuropeptides in neurones and of their concentration in the medial eminence.
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