Relationships between serum osteocalcin levels and C-peptide in post-traumatic male patients

Abstract

Objective To investigate the relationships between serum osteocalcin (OC) levels and glycometabolism markers in nondiabetic post-traumatic male patients. Methods Populaitons were selected at the Department of Emergency Medicine of Shanghai Jiao Tong University Affiliated Sixth People’s Hospital from October 2017 to February 2019. The age, injury severity score (ISS), and characteristic indicators were recorded. The inclusion criteria were age ≥18 years and blood collection time 7.8 mmol/L) and nonstress hyperglycemia (NO-SH) (FPG≤7.8 mmol/L) groups. The fasting venous blood samples were collected and examined. The characteristics and biochemical indicators in the two groups were compared statistically by LSD-t test, rank sum test and ANOVA, and the relationships between serum OC levels and glycometabolism markers were analyzed by partial correlation analysis. Results A total of 395 traumatic patients were enrolled and divided into the SH group (n=182) and NO-SH group (n=213). There were no differences in ISS, fasting insulin (FINS), and C-peptide (C-P) levels between groups. Age, HbA1c and FPG were higher (P=0.041, P=0.037, P<0.01), while the OC level was lower (P=0.023), in the SH group than those in the NO-SH group. The serum OC level did not correlate with HbA1c, FPG, and FINS, but negatively correlated with C-P by partial correlation analysis (r=-0.262, P=0.008). The multivariate linear regression analysis showed that C-P was an independent factor affecting serum OC levels after trauma (β= -0.655, P=0.043). Conclusion A correlation existed between the serum OC level and glycometabolism markers in nondiabetic post-traumatic male patients. Key words: C-peptide; Osteocalcin; Stress hyperglycemia; Trauma