Abstract
Objective To explore the effectiveness of different peak negative pressure ultrasound irradiated microbubble destruction on the control of rat blood brain barrier permeability. Methods Thirty healthy SD rats were divided into 5 groups according to different ultrasound pressure level (62 kPa, 86 kPa, 181 kPa, 324 kPa, 708 kPa). After intravenous injection of microbubble, the rats were underwent ultrasonic irradiation for 9 minutes, and the contralateral hemispheres were served as controls. The permeability of blood brain barrier was determined by the quantitative analysis of Evans blue and lanthanum nitrate extravasation. Results Quantitative analysis results revealed a leakage in Evans blue about(4.52±0.11) μg/g and (10.56±0.13)μg/g in group 181 kPa and 708 kPa, respectively. A wide endothelial cell gap with lanthanum nitrate trace leaked out was shown at the group of ultrasound pressure of 181 kPa, and erythrocytes extravasations were found when ultrasound pressure at 708 kPa. Conclusions The pressure amplitude in microbubble enhanced cavitation can effectively regulate and control blood-brain barrier opening in rats. Key words: Blood-brain barrier; Microbubblest; Cavitation; Hemicerebrum; Rat
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