Abstract
The present study aimed to investigate the influence of UGT1A9 gene polymorphisms on the efficacy of propofol in patients undergoing the painless induced abortion method. A total of 156 women seeking voluntary pregnancy termination procedures were selected for the study, and subsequently underwent painless induced abortions, following anesthesia by means of propofol administration. PCR-restriction fragment length polymorphism (PCR-RFLP) was performed to detect the polymorphisms of UGT1A9 gene at –440C/T, –1818C/T, and –1887T/G loci. The time, effect-site concentration, and bispectral index (BIS) for the Observer’s Assessment of Alertness/Sedation (OAA/S) (up to 4 points) were observed and recorded in patients following discontinuation of propofol. The time and effect-site concentration for BIS reaching 80 in patients following the discontinuation of propofol were observed and recorded. Postoperative observations of adverse reactions, such as nausea, vomiting, and respiratory depression were all made record of. In comparison with patients with UGT1A9 –440C/T CT and TT, those with UGT1A9 –440C/T CC displayed shorter durations of OAA/S by up to 4 points, shorter BIS times reaching 80, as well as higher corresponding effect-site concentrations. No significant differences were detected in the patients with –440C/T, –1818T/C, and –1887T/G in incidence of nausea, vomiting, and respiratory depression. The findings of the study highlighted correlation between UGT1A9 –440C/T gene polymorphisms and positive propofol efficacy in patients undergoing painless induced pregnancy termination procedures.
Highlights
Induced abortion represents the most frequent outpatient surgical procedure amongst the female population
Anesthesia is not without its own set of risk factors as well as the requirement of a diligent process of anesthesia preparation, including anesthesia equipment, clinical skills of anesthesiologists, selection of anesthetics, and dose deviation of anesthetic drugs, which without adequate attention may result in loss of life
Gene variation may take place at the genetic level, and single nucleotide polymorphism (SNP) remains the most stable as well as the most common genetic variation at present identified amongst individuals [18]
Summary
Induced abortion represents the most frequent outpatient surgical procedure amongst the female population. 46 million induced abortion procedures are performed worldwide on an annual basis. Propofol is widely used due to its numerous advantages, including easy regulation of the anesthesia depth, short time to recover consciousness, and less postoperative nausea and vomiting c 2017 The Author(s).
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