Relationship between intact parathyroid hormone and all-cause death, cardiovascular events, and ectopic calcification in patients with diabetic kidney disease: A retrospective study

Abstract

AimWe aimed to investigate the relationship between intact parathyroid hormone (iPTH) levels and all-cause death, cardiovascular events, and ectopic calcification in patients with diabetic kidney disease (DKD). MethodsIn this retrospective cohort study, we collected the clinical data of 508 patients with clinically diagnosed DKD. The primary and secondary outcomes were all-cause death or cardiovascular events and ectopic calcification, respectively. We used different regression methods to analyze the relationship between various clinical parameters and the two clinical outcomes. ResultsWe found that iPTH was a risk factor for all-cause death and cardiovascular events (hazards ration [HR]: 2.817, 95% confidence interval [CI]: 1.045–6.562, P = 0.016). Meanwhile, diabetes duration (HR: 1.090, 95% CI: 1.045–1.138, P < 0.0001), triglycerides (TG) (HR: 1.254, 95% CI: 1.049–1.499, P = 0.013), and iPTH (HR: 1.954, 95% CI: 1.001–3.813, P = 0.049) were independent risk factors for ectopic calcification. In contrast to patients with lower iPTH levels (iPTH < 31.7 pg/mL), patients with higher iPTH levels (iPTH ≥ 31.7 pg/mL) had increased ectopic calcification rate (P = 0.002) and decreased survival time (P < 0.001). ConclusionIn patients with DKD, higher iPTH levels were significantly related to worsen clinical outcomes.