Relationship between insulin resistance, incidence of fatty liver and serum ferritin level in adults with simple obesity

Abstract

Objective To explore the relationship of serum ferritin with insluin resistance(IR) and incidence of fatty liver in adults with simple obesity. Methods According to body mass index (BMI), 78 adults with simple obesity were divided into three groups, including 34 cases in Ⅰ degree obesity group, 30 cases in Ⅱ degree obesity group and 14 cases in Ⅲ degree obesity group, and 35 adults with simple overweight and 67 healthy adults were also enrolled as control group.The height, weight, waistline, hip circumference, incidence of fatty liver, fasting blood glucose (FBG), fasting insulin (FIN), blood lipids and ferritin(SF) level were tested, and the body mass index (BMI), WHR and IR index (HOMA-IR) were calculated. Results When BMI increased, levels of SF, HOMA-IR, FBG, FIN, triglyceride(TG), cholesterol(TC), low density lipoprotein-cholesterol (LDL-C) were gradually increased(F=378.92, 12.01, 55.50, 123.96, 90.09, 127.65, 23.81, all P<0.01). However, high density lipoprotein-cholesterol (HDL-C) was gradually degraded(F=114.56, P<0.01). The incidence of fatty liver had significant differences in Ⅰ, Ⅱ, Ⅲ degree obesity groups((t=24.872, 7.885, all P<0.01), and with the degree of obesity increased, the rate of fatty liver increased significantly.SF range interquartile and level in fatty liver group was significantly greater than the non fatty liver group, the difference was statistically significant (t=22.99, P<0.01). SF was positively correlated with BMI, WRH, FBG, FIN, HOMA-IR, TC, TG, LDL-C (r=0.863, 0.719, 0.789, 0.703, 0.617, 0.785, 0.717, 0.771, all P<0.01), and negatively correlated with HDL-C(r=-0.530, P<0.01). Multiple stepwise regression analysis indicated that BMI, FIN, LDL-C, HOMA-IR were independent risk factors affecting SF(t=4.646, 2.595, -5.073, 6.666, all P<0.01). SF, BMI, FBG, FIN, LDL-C were independent risk factors influencing HOMA-IR(t=6.535, 3.254, 18.827, 61.227, 2.154, all P<0.05). Conclusion Simple obesity adults had obvious blood lipid disorders and IR, easy to complicated with fatty liver, the incidence of fatty liver associated with severity of obesity, the overexpression of SF is closely related to it. Key words: Obesity; Ferritin; Insulin resistance