Abstract
Objective:To investigate the relationship between the distribution and quantity of memory T lymphocytes, dendritic cells (DCs) and cytotoxic T lymphocytes in the tumor microenvironment and the prognosis of gastric carcinoma. Methods:Immunohistochemistry was used to assess the densities of CD45RO+,CD11c+ and CD8+ cells in the tumor microenvironment of 60 gastric cancer cases.These densities were evaluated for associations with clinicopathologic characteristics and survival.Results:The density of memory T lymphocytes,dendritic cells (DCs) and cytotoxic T lymphocytes in the tumor microenvironment was negatively correlated with regional lymph node metastasis.Kaplan-Meier survival analysis revealed that patients in the high-density groups for CD45RO+T,CD11c+ (DCs),CD8+ T and CD45RO+TCD11c+ (DCs) CD8+ T had a significantly longer survival time than those in the corresponding low-density groups.Furthermore lymphatic metastasis,TNM stage and diameter of the primary tumor were correlated with the prognosis.In multivariate survival analysis, the density of CD45RO+ T cells and lymph node metastasis remained independent prognostic factors with hazard ratios (95% CI) of 0.437 (0.192-0.992) and 2.330 (1.136-4.779),respectively.Conclusion:Immunocyte density is predictive of lymph node metastasis.The density of CD45RO+T cells can be used as an independent prognostic factor.
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