Abstract
Background: Breast cancer is the most common malignancy among women worldwide. The treatments may also cause neuromuscular and skeletal disorders; therefore, the aim of this study was to verify the existence of a relationship between heart rate variability and different functional fitness parameters in women survivors of breast cancer. Methods: This cross-sectional study included 25 women survivors of breast cancer, with a mean ± SD age, height, and body mass of 50.8 ± 8.8 years, 1.6 ± 0.7 m, and 67.1 ± 12.3 kg, respectively. Patients underwent measurements of heart rate variability with time and frequency domain analyses, as well as a “30 s chair-stand test”, “6 min walking test”, “timed up and go test”, and “ball throwing test”. Results: A multiple linear regression analysis showed that from the heart rate variability frequency domain, high frequency explained 21% (R2 = 0.21) of the “30 s chair-stand test” performance. Conclusion: The findings of this study highlight high frequency as a predictor of “30 s chair-stand test” performance, regardless of age and time after diagnosis, suggesting its usefulness as a clinical indicator of functionality in breast cancer survivors. This study presents a straightforward and non-invasive methodology predicting functional fitness in women breast cancer survivors potentially applicable to clinical practice.
Highlights
The breast cancer (BC) mortality rate has been decreasing due to advances in treatments, the survival of a cancer patient varies greatly according to the type of cancer, the stage, and the age at diagnosis [2]
The present study arose from the unmet need to create a straightforward, replicable, and non-invasive approach, which for this population is essential and would relate functional fitness and cardiac autonomic control; the aim of the present study was to verify the existence of a relationship between vagus nerve activity assessed by Heart rate variability (HRV)
Body mass index (BMI) values were classified as underweight (n = 0, 0%), normal weight (n = 11, 44%), overweight (n = 8, 32%), or obese (n = 6, 24%)
Summary
Oncological diseases such as breast cancer (BC) are a global public health problem with high incidence and mortality in developed countries. The treatments may cause neuromuscular and skeletal disorders; the aim of this study was to verify the existence of a relationship between heart rate variability and different functional fitness parameters in women survivors of breast cancer. Patients underwent measurements of heart rate variability with time and frequency domain analyses, as well as a “30 s chair-stand test”,. Conclusion: The findings of this study highlight high frequency as a predictor of “30 s chair-stand test” performance, regardless of age and time after diagnosis, suggesting its usefulness as a clinical indicator of functionality in breast cancer survivors. This study presents a straightforward and non-invasive methodology predicting functional fitness in women breast cancer survivors potentially applicable to clinical practice
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