Abstract
BackgroundAseptic loosening is a main cause for revision surgery after total hip arthroplasty (THA) and there is no reliable marker for the early detection of patients at high risk. This study has been performed to validate association of the T393C polymorphism (rs7121) in the GNAS1 gene, encoding for the alpha-subunit of heterotrimeric G-protein Gs, with risk for and time to aseptic loosening after THA, which has been demonstrated in our previous study.Methods231 patients with primary THA and 234 patients suffering from aseptic loosening were genotyped for dependency on GNAS1 genotypes and analyzed.ResultsGenotyping revealed almost similar minor allele frequencies of 0.49 and 0.46, respectively. Consistently, genotype distributions of both groups were not significantly different (p = 0.572). Neither gender nor GNAS1 genotype showed a statistically significant association with time to loosening (p = 0.501 and p = 0.840). Stratification by gender, as performed in our previous study, was not able to show a significant genotype-dependent difference in time (female p = 0.313; male p = 0.584) as well as median time to aseptic loosening (female p = 0.353; male p = 0.868).ConclusionThis study was not able to confirm the results of our preliminary study. An association of the GNAS1 T393C polymorphisms with risk for and time to aseptic loosening after THA is unlikely.
Highlights
Aseptic loosening is a main cause for revision surgery after total hip arthroplasty (THA) and there is no reliable marker for the early detection of patients at high risk
GNAS1 T393C genotype distribution in 234 patients suffering from aseptic loosening after THA was 44 TT genotype carriers, 126 heterozygous patients and 64 carried the CC genotype
We investigated the impact of the single-nucleotide polymorphism T393C in the GNAS1 gene locus on time and median time to aseptic loosening
Summary
Aseptic loosening is a main cause for revision surgery after total hip arthroplasty (THA) and there is no reliable marker for the early detection of patients at high risk. The number of total hip arthroplasties (THA) will increase noticeably in the years. Revision surgery after THA is often needed due to instability, infection as well as aseptic loosening [2]. This leads to a predicted doubling of the number of revision surgeries after THA by the year 2026 [1]. The identification of risk factors influencing time to aseptic loosening may result in a better outcome of patients with THA by application of specific prophylactic treatments prior or subsequent to surgery. Some studies investigating the impact of genetic host factors on aseptic loosening have been published [7, 8]
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