Abstract
BackgroundOverweight/obesity has been reported to worsen pulmonary function (PF). This study aimed to examine the association between PF and several body composition (BC) measures in two population-based cohorts.MethodsWe performed a cross-sectional analysis of individuals aged 18 and 30 years from two Pelotas Birth Cohorts in southern Brazil. PF was assessed by spirometry. Body measures that were collected included body mass index, waist circumference, skinfold thickness, percentages of total and segmented (trunk, arms and legs) fat mass (FM) and total fat-free mass (FFM). FM and FFM were measured by air-displacement plethysmography (BODPOD) and by dual-energy x-ray absorptiometry (DXA). Associations were verified through linear regressions stratified by sex, and adjusted for weight, height, skin color, and socioeconomic, behavioral, and perinatal variables.ResultsA total of 7347 individuals were included in the analyses (3438 and 3909 at 30 and 18 years, respectively). Most BC measures showed a significant positive association between PF and FFM, and a negative association with FM. For each additional percentage point of FM, measured by BOD POD, the forced vital capacity regression coefficient adjusted by height, weight and skin color, at 18 years, was −33 mL (95% CI −38, −29) and −26 mL (95% CI −30, −22), and −30 mL (95% CI −35, −25) and −19 mL (95% CI −23, −14) at 30 years, in men and women, respectively. All the BOD POD regression coefficients for FFM were the same as for the FM coefficients, but in a positive trend (p<0.001 for all associations).ConclusionsAll measures that distinguish FM from FFM (skinfold thickness–FM estimation–BOD POD, total and segmental DXA measures–FM and FFM proportions) showed negative trends in the association of FM with PF for both ages and sexes. On the other hand, FFM showed a positive association with PF.
Highlights
Overweight/obesity is a growing risk factor in most countries worldwide [1]
fat mass (FM) and fat-free mass (FFM) were measured by air-displacement plethysmography (BODPOD) and by dual-energy x-ray absorptiometry (DXA)
For each additional percentage point of FM, measured by BOD POD, the forced vital capacity regression coefficient adjusted by height, weight and skin color, at 18 years, was −33 mL and −26 mL, and −30 mL and −19 mL at 30 years, in men and women, respectively
Summary
Overweight/obesity is a growing risk factor in most countries worldwide [1] This condition has been reported as an aggravating factor for many respiratory diseases or symptoms, such as obstructive sleep apnea, asthma, and dyspnea on effort, among others [2, 3]. Many studies have shown that obesity is associated to lower pulmonary function (PF) measures, even in non-diseased individuals [4, 5]. These findings have been attributed to the restriction and load imposed by excess fat mass (FM) on ventilatory mechanics [6, 7]. This study aimed to examine the association between PF and several body composition (BC) measures in two population-based cohorts
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.