Relationship Between Aerobic Capacity With Oxidative Stress and Inflammation Biomarkers in the Blood of Older Mexican Urban-Dwelling Population.

Abstract

The maximal oxygen uptake (VO2max) constitutes an indicator of an organism’s capacity to integrate oxygen into the metabolism to obtaining energy. The aim of this study was to determine the relationship between VO2max and oxidative stress (OxS) and chronic inflammation in the elderly individuals. A cross-sectional and exploratory study was conducted in a sample of 52 older persons. We measured plasma lipid peroxides (LPO), red blood cell glutathione peroxidase, red blood cell superoxide dismutase, and total antioxidant status. The interleukin 10 and tumor necrosis factor-α (TNF-α) were measured in serum by ELISA. The VO2max was determined by the Rockport aerobic test, and the energy expenditure (caloric expenditure and metabolic equivalence unit (MET) per day) was measured by a 3-day activity record. We observed a positive correlation between VO2 max with IL-10, MET/day•day-1 and kcal•day-1 (r = 0.31, P < .05, r = 0.44, P < .01, and r = 0.29, P < .05, respectively), and a negative correlation with the body mass index, TNF-α, and LPO (r = −0.27, P < .05, r = −0.29, P < .05, and r = −0.40, P < .01 respectively). Our findings suggest that there is an inverse relationship between the aerobic capacity and the OxS and chronic inflammation biomarkers in the blood in older Mexican adults.