Abstract
IN SEEKING the nature of the factors underlying the sexual differences in immunity to syphilis, we undertook an experimental study of the disease in male rabbits feminized by prolonged administration of an estrogenic substance (1, 2). This substance, prepared from a butyl alcoholic extract of human pregnancy urine, was capable of inducing estrous effects in ovariectomized rats. When given to adult male rabbits, there resulted a series of anatomical changes, including partial metamorphosis of the external genitalia, and the development of certain female secondary sex characters (1, 3). When the testis was the site of inoculation, the feminized rabbits responded with a milder form of syphilis than the sexually intact male rabbits. This was true of both the primary testicular and the generalized metastatic phenomena of the disease.
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