Relation entre le strain de l’oreillette gauche, la dysfonction ventriculaire gauche et le pronostic dans le rétrécissement aortique

Abstract

Background Left atrial (LA) function is increasingly used to predict cardiovascular events. Objective We tested the relationship between LA strain (Las) and left ventricular dysfunction and prognosis in aortic stenosis (AS). Methods Transthoracic Doppler echocardiography was performed prospectively in 98 consecutive patients with AS (63 with severe, 35 with moderate AS, mean age 77 ± 10 years, 49% women, mean aortic valve area 0.5 ± 0.15 cm2, mean LVEF 63 ± 13%). LA volume was calculated by the area-length method in apical four-and two-chamber views and indexed to body surface area. Las (mean of maximal strain from the 4-2-3 chamber views) was conducted using a dedicated software package, using R-R gating. The end-point was hospitalization for heart failure and death from any cause. Results Las, and LA volume/mLas were significantly correlated to E/A, E/e’, and pulmonary artery systolic pressure (all, P Conclusion In patients with moderate to severe AS, Las is associated with LV diastolic and systolic dysfunction, AS severity, and is independently linked to events.