Relation between the hypertension and benign prostatic hyperplasia in the elderly

Abstract

Increasing longevity in the developed world means an increasing prevalence of age-related disorders such as hypertension and benign prostatic hyperplasia (BHP). In Vietnam, the prevalence of hypertension has also increased along with age from 4.3% for 15–40 years old to 47.7% for 70 years and older. The spontaneously hyperplasia of the prostate in aging genetic hypertensive rats have shown. Therefore, the aim of this study was to assess the relationship between BHP and hypertension in the elderly. A total of 212 males from 60 years and older were prospectively and randomly studied between January 2000 and October 2000 and were divided into two groups: a hypertensive group and a control group. Hypertension is defined as systolic blood pressure of 140mmHg or greater, diastolic blood pressure of 90 mmHg or greater in people who are not taking antihypertensive medication following the criteria of JNC-VI and 1999 WHO/ISH guidelines. Clinical histories, full physical examinations, laboratory tests and IPSS-L questionnaires and prostates echographies were conducted following the diagnostic guidelines of the Third International Committee by WHO. We noted mean prostate volume was 22028,86±10607,78 mm3 with hypertensive group was 24325,46 ±12240,93% and control group was 19732,26±8101,36mm3. Compare mean by T test: Mean difference: 4593,11. 95% Confidence Interval (7403,81-1782,59) P (2 tailed) =0.001. Analyze of logistic regression noted variables in the Equation: Wald = 9,15, OR 1, 95% CI (1-1.0001) P=0.002. Of these cases, 59.15% of BHP had the symptoms of I-PSS > 8 scores. The majority of the studying subjects were not constantly concerned with the lower urinary tract symptoms. There was a significant correlation between mean blood pressure and prostate size in all of subjects with the correlation coefficient r (2) = 0,205 P <0, 01. The elderly hypertensive patients need to be observed about the symptoms and echography of BHP for earlier treatment with the selective antihypertensive therapy and the other treatment options to improve in quality of life.