Abstract
<h3>Introduction</h3> Around 70–90% of typical NMO have aquaporin-4 antibodies (AQP4-Ab). More recently, an association between myelin oligodendrocyte glycoprotein antibodies (MOG-Ab) and monophasic NMO has been reported. <h3>Methods</h3> We present 5 AQP4-Ab negative cases with relapsing CNS demyelinating disease (4 with NMO phenotype) associated with MOG-Ab. <h3>Results</h3> All patients were Caucasian. Four patients presented with typical NMO phenotype. One patient had a long myelitis and a further brainstem event. Median age at onset was 17 (16–39) years. The first episode of optic neuritis and longitudinally extensive myelitis developed simultaneously in 2 patients while 2 patients had inter-attack interval 1.1 and 7 years. All except one patient had a normal brain MRI. EDSS (visual) scores after disease duration (number of relapses) of 1.3 (2), 1.6 (2), 3.4 (6), 8.3 (7) and 12 (13) years were 5 (0), 4 (3), 3 (5), 4 (0) and 4 (6) respectively. <h3>Conclusions</h3> MOG-Ab can be seen in relapsing NMO and is not restricted to the monophasic subtype. The clinical and diagnostic role of MOG-Ab is still evolving.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: Journal of Neurology, Neurosurgery & Psychiatry
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
