Abstract
Brain repair after stroke is entering an exciting stage. The four articles on this topic that follow examine a number of the forefronts, including translational efforts, new drug discovery, brain mapping to measure reorganization in humans, new national structures for expanding trials in this setting, the interplay between repair and experience, and the various therapeutic approaches under investigation. Dr Larry Goldstein summarizes the many clinical trials conducted on the effects of d-amphetamine in stroke survivors. This drug has been repeatedly shown to be beneficial in animal models, especially when combined with behavioral experience. However, results of clinical trials have been quite variable, possibly related to differences in dosing regimens, timing with respect to physiotherapy, or other factors related to …
Highlights
Dr Larry Goldstein summarizes the many clinical trials conducted on the effects of d-amphetamine in stroke survivors
Results of clinical trials have been quite variable, possibly related to differences in dosing regimens, timing with respect to physiotherapy, or other factors related to stroke severity
Dr Goldstein emphasizes the critical issues of trial design in evaluating amphetamine trials in stroke recovery, including the importance of coupling drug exposure with the experience of physiotherapy, and concludes that the effectiveness of this drug remains unanswered
Summary
The four articles on this topic that follow examine a number of the forefronts, including translational efforts, new drug discovery, brain mapping to measure reorganization in humans, new national structures for expanding trials in this setting, the interplay between repair and experience, and the various therapeutic approaches under investigation. Dr Larry Goldstein summarizes the many clinical trials conducted on the effects of d-amphetamine in stroke survivors. Dr Goldstein emphasizes the critical issues of trial design in evaluating amphetamine trials in stroke recovery, including the importance of coupling drug exposure with the experience of physiotherapy, and concludes that the effectiveness of this drug remains unanswered. Dr Theresa Jones and colleagues review the evidence for the effects of behavioral experience on the anatomy of dendrites and synapses in the remaining intact cortical tissue after injury.
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