Abstract The huge market of food products has been dramatically influenced by nanotechnology. Nanomaterials have entered the food industry in different manufacturing and packaging processes. However, nanomaterials have some potential toxicities and after high consumption rates, environmental and various human health concerns were raised which necessitates the establishment of rules and guidelines for food-related nanomaterials around the world. Regulation and legislation of food nanomaterials is an almost new and developing concept. Although some countries have published regulations and guidance regarding the safety of food nanomaterials but most of them are relying on non-legally binding guidance and standards. Reviewing the regulatory principles of different countries helps to share information and provides a global collaboration for safe and regulated manufacturing of these products. In this chapter, possible nanotechnology-related regulatory aspects and principles used in food industry in North and South American countries are reviewed and their pros and cons are discussed.

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