Abstract
Adenocarcinoma of lung has high incidence and a poor prognosis, woith chemotherapy as the main therapeutic tool, most commonly with cisplatin. However, chemotherapy resistance develops in the majority of patients during clinic treatment. Mechanisms of resistance are complex and still unclear. Although annexin play important roles in various tumor resistance mechanisms, their actions in cisplatin-resistant lung adenocarcinoma remain unclear. Preliminary studies by our group found that in cisplatin-resistant lung cancer A549 cells and lung adenocarcinoma tissues, both mRNA and protein expression of annexins A1, A2 and A3 is increased. Using a library of annexin A1, A2 and A3 targeting combined molecules already established by ourselves we found that specific targeting decreased cisplatin-resistance. Taken together, the underlined effects of annexins A1, A2 and A3 on drug resistance and suggest molecular mechanisms in cisplatin-resistant A549 cells both in vivo and in vitro. Furthermore, the study points to improved research on occurrence and development of lung adenocarcinoma, with provision of effective targets and programmes for lung adenocarcinoma therapy in the clinic.
Highlights
Lung cancer, with its rapidly growing morbidity, is one of the common malignancies that ranks among the top in the incidence of cancer among adults, and has become the most common cause of human death from tumors (Sun et al, 2014)
The drug resistance produced by tumor cells marks the most universal and difficult problem that influences the curative effect of chemotherapy, and the main reason that leads to chemotherapy failure
To further reveal the critical role of Annexin A1, A2 and A3 in cisplatin resistance in vivo, we observed the expression of Annexin A1, A2 and A3 in tumor tissues of lung adenocarcinoma patients
Summary
With its rapidly growing morbidity, is one of the common malignancies that ranks among the top in the incidence of cancer among adults, and has become the most common cause of human death from tumors (Sun et al, 2014). As the first line drug, is extensively applied for the clinical treatment of nonsmall-cell lung cancer (Fan and Jiang, 2008). The drug resistance produced by tumor cells marks the most universal and difficult problem that influences the curative effect of chemotherapy, and the main reason that leads to chemotherapy failure. Conducting indepth research on the new action mechanism of cisplatin on adenocarcinoma and discovering key molecules that play significant roles may lead to more effective candidate targets and treatment plans for adenocarcinoma. Many studies indicate that Annexins (A1, A2, and A3) play significant roles in the growth of various tumors and the production of drug resistance, which mark good target spots for tumor treatment (Mussunoor and Murray, 2008; Protzel et al, 2010)
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