Abstract
Type 1 diabetes mellitus (T1DM) is an autoimmune disorder characterized by the T cell-mediated destruction of islet β cells. However, B cells also play critical roles in the occurrence and development of T1DM. B cells depletion could be used in the treatment of T1DM. To date, regulatory B cells(Bregs), as immunosuppressive B cells, have been shown to play pivotal roles in the control of autoimmunity and pathological immune responses. Bregs are numerically and functionally impaired in T1DM. Investigation of Bregs in the pathogenesis of T1DM will further provide the theoretical evidences and explore new targets and new ideas for the treatment of T1DM. Key words: Regulatory B cells; Type 1 diabetes mellitus; Autoimmune diseases
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