Abstract
The effect of ascorbate in physiological concentrations on the proliferative activity and chemoresistance in human larynx carcinoma HEp-2 cells was studied. Ascorbate in a concentration of 60 μM was found to increase the cancer cells proliferation rate 1.5 times. Ascorbate changes the functional state of the cancer cells, thereby increasing their resistance to doxorubicin and thymoquinone. It was shown that apocynin (NADPH oxidase inhibitor) blocks the stimulating effect of the antioxidant. The results obtained suggest that reactive oxygen species produced by NADPH oxidase participate in the mechanism of cell adaptive response induced by ascorbate.
Highlights
Для определения влияния аскорбата на пролиферативную активность опухолевых клеток использовали антиоксидант в концентрациях от 10 до 200 мкМ
Redox regulation of calcium signaling in cancer cells by ascorbic acid involving the mitochondrial electron transport chain / G
Summary
Для определения влияния аскорбата на пролиферативную активность опухолевых клеток использовали антиоксидант в концентрациях от 10 до 200 мкМ. При введении аскорбата в культуру в концентрациях от 10 до 40 мкМ скорость роста клеток карциномы гортани человека линии НЕр-2 не изменялась При культивировании клеток с аскорбатом в концентрациях от 40 до 100 мкМ скорость роста опухолевых клеток была выше, чем в контроле.
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