Abstract
1. 1. Ornithine decarboxylase is active in kidney and heart muscle, less so in brain, pancreas and intestinal mucosa extracts, but in every case more than in liver. 2. 2. S-adenosylmethionine decarboxylase is also active in the same tissues, with maximal activity in heart, brain and pancreas. 3. 3. Insulin induces both enzymes in all tissues, with the exception of brain, where activity is somewhat decreased. 4. 4. Spermidine partially prevents induction by insulin in pancreas. 5. 5. In the pancreas putrescine, spermidine and spermine levels are very high, with a spermidine/spermine ratio 1.80. Insulin promotes an increase of putrescine and a decrease of spermidine. Administration of spermine promotes modifications in polyamine levels lower than in liver, but of the same kind.
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