Abstract
Embryonic stem (ES) are cells that have the ability to divide for an indefinite period.Under the right conditions and given the right signals, they can give rise to precursors of one or more specialised cells.Although they are derived from the inner cell mass (ICM) of human blastocyst, it is still uncertain precisely which stage of ICM development the ES cells correspond to, what controls their maintenance as pluripotent progenitors and which signals can initiate differentiation. This study addresses the regulation of cell fate decision within the human ICM by analysing expression of genes in the preimplantation human embryos, human embryonal carcinoma (hEC) cells and hES cells.
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