Abstract
Membrane receptors are known to be targets of the majority of modern drugs. However, alterations of these receptors in diseases, causes of these alterations, and their relations with the development of diseases are studied only in few cases. This review considers some mechanisms of regulation of activity and expression of G-protein-coupled receptors (GPCRs) that comprise the largest family of membrane proteins. Data are presented on hereditary diseases caused by genetic deficiencies of receptors, and on oncological diseases caused by somatic mutations of GPCR(s) and G-protein(s) genes. The relation is discussed between the development of diseases and disorders in the receptor functioning that appear during ontogenesis. In the final part of the review our own data are presented on the state of the receptors of vasoconstrictive hormones and neurotransmitters in blood vessels under the conditions of traumatic shock.
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