Abstract
Objective: Aromatase P450 (P450arom), the key enzyme in the biosynthesis of estrogen, is expressed aberrantly in endometriosis tissue. In human ectopic endometriotic stromal cells, markedly high levels of P450arom mRNA and activity are present and can be vigorously stimulated by dibutyryl (Bt2) cAMP or PGE2 to give rise to physiologically significant estrogen biosynthesis. On the other hand, eutopic endometrial tissue or stomal cells lack P450arom expression. We sought to determine herein the molecular basis for the presence of P450arom expression in endometriosis and its absence in eutopic endometrium.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
